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Rewriting the genome produces mouse models of human illnesses


Many human diseases lack accurate mouse models because it is technically difficult to create extensively genetically humanized mice. A technique that allows large stretches of DNA to be rapidly rewritten in mouse embryonic stem cells can be used to produce improved animal models.

This is a summary of: Zhang, W. et al. Mouse genome rewriting and tailoring of three important disease loci. Nature https://doi.org/10.1038/s41586-023-06675-4 (2023).

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doi: https://doi.org/10.1038/d41586-023-03079-2

Figure 1 is published under a CC BY 4.0 licence.


  1. Boeke, J. D. et al. Science 353, 126–127 (2016).

    Article  PubMed  Google Scholar 

  2. Richardson, S. M. et al. Science 355, 1040–1044 (2017).

    Article  PubMed  Google Scholar 

  3. Zheng, J. et al. Nature 589, 603–607 (2021).

    Article  PubMed  Google Scholar 

  4. Hoffmann, M. et al. Cell 181, 271–280 (2020).

    Article  PubMed  Google Scholar 

  5. DeWolf, S. et al. Immunity 55, 1779–1798 (2022).

    Article  PubMed  Google Scholar 

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