- RESEARCH BRIEFINGS
Many human diseases lack accurate mouse models because it is technically difficult to create extensively genetically humanized mice. A technique that allows large stretches of DNA to be rapidly rewritten in mouse embryonic stem cells can be used to produce improved animal models.
This is a summary of: Zhang, W. et al. Mouse genome rewriting and tailoring of three important disease loci. Nature https://doi.org/10.1038/s41586-023-06675-4 (2023).
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doi: https://doi.org/10.1038/d41586-023-03079-2
Figure 1 is published under a CC BY 4.0 licence.
References
Boeke, J. D. et al. Science 353, 126–127 (2016).
Richardson, S. M. et al. Science 355, 1040–1044 (2017).
Zheng, J. et al. Nature 589, 603–607 (2021).
Hoffmann, M. et al. Cell 181, 271–280 (2020).
DeWolf, S. et al. Immunity 55, 1779–1798 (2022).
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