header banner
Default

Rewriting the genome produces mouse models of human illnesses


  • RESEARCH BRIEFINGS

Many human diseases lack accurate mouse models because it is technically difficult to create extensively genetically humanized mice. A technique that allows large stretches of DNA to be rapidly rewritten in mouse embryonic stem cells can be used to produce improved animal models.

This is a summary of: Zhang, W. et al. Mouse genome rewriting and tailoring of three important disease loci. Nature https://doi.org/10.1038/s41586-023-06675-4 (2023).

Access options

Access Nature and 54 other Nature Portfolio journals

Get Nature+, our best-value online-access subscription

$29.99 / 30 days

cancel any time

Subscribe to this journal

Receive 51 print issues and online access

$199.00 per year

only $3.90 per issue

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

doi: https://doi.org/10.1038/d41586-023-03079-2

Figure 1 is published under a CC BY 4.0 licence.

References

  1. Boeke, J. D. et al. Science 353, 126–127 (2016).

    Article  PubMed  Google Scholar 

  2. Richardson, S. M. et al. Science 355, 1040–1044 (2017).

    Article  PubMed  Google Scholar 

  3. Zheng, J. et al. Nature 589, 603–607 (2021).

    Article  PubMed  Google Scholar 

  4. Hoffmann, M. et al. Cell 181, 271–280 (2020).

    Article  PubMed  Google Scholar 

  5. DeWolf, S. et al. Immunity 55, 1779–1798 (2022).

    Article  PubMed  Google Scholar 

Download references

Subjects

Latest on:

Sources


Article information

Author: Destiny Harris

Last Updated: 1700186041

Views: 1283

Rating: 3.9 / 5 (40 voted)

Reviews: 97% of readers found this page helpful

Author information

Name: Destiny Harris

Birthday: 1980-07-24

Address: 6484 Morrison Expressway, Emilyview, NJ 89329

Phone: +4692022028056509

Job: Data Analyst

Hobby: Puzzle Solving, Playing Guitar, Cycling, Ice Skating, Metalworking, Bird Watching, Arduino

Introduction: My name is Destiny Harris, I am a persistent, valuable, ingenious, resolute, unswerving, steadfast, Determined person who loves writing and wants to share my knowledge and understanding with you.